Everything You Need To Know About Metabolites.

Metabolites: Metabolites are the intermediate products that are formed while the metabolic reactions takes place to form the final product

Example : 4-Hydroxypropranolol Hydrochloride
                                 
Metabolite of : Propranolol

Uses: Propanolol Hydrochloride is a beta- adrenergic receptor blocking agent ( Usually used in the management of hypertension drugs

                          
Deuterium Labelled Compounds :

• These come under stable labelled Isotopes

• Deuteration has no effect on Biological potency or selectivity

• Potential for drug to have longer half life and reduced/less frequent dosing

• Improve metabolite profile : prevent formation of toxic metabolites

Metabolites

Example : (+/-)-4-Hydroxy Propranolol-d7 Hydrochloride
It is a labelled metabolite of Propanolol